Benedick B. Borbe,
Valerie Anne R. Flores,
Aron Heinrich C. Go,
John Philip T. Lim,
Ma. Anna Alexandra M. Mosa,
Catrina Theresa M. Yang
Ateneo de Manila University
Proton Pump Inhibitors and H2 Blockers are commonly available over-the-counter medications for the treatment of a myriad of acid reflux and hyperacidity disorders of the GI tract. It has been pointed that these drugs have the ability to change gastric and colonic environments, hence possibly making one susceptible to life-threatening infections from both opportunistic pathogens and resident flora such as Clostridium difficile. With this in mind, the group would like to determine a possible association between the intake of the said drugs and the contraction of C. difficile-Associated Diseases (CDAD) of patients previously confined in a private tertiary hospital in Pasig City. Through a retrospective analysis of patient hospital records, this case control study will delineate a possible statistical association between the drugs and the disease. Statistical analysis of results will be performed through univariate, bivariate and multivariate methods.
General Objective: The main research objective of this study is to establish the possible presence of a statistically significant association between PPI- and H2 blocker-use and contraction of C. difficile-Associated Disease (CDAD) in patients hospitalized in a private hospital in Pasig City.
The following are the study's secondary research objectives:
1.To determine if prolonged use of the said drugs could be attributed either as an independent or co-dependent risk factor for CDAD.
2.To determine the proportion of H2-Blocker and Proton Pump Inhibitor-Induced CDAD among hospital patients.
3.To determine, if present, the contributory effect of H2 blockers and/or proton pump inhibitors in combination with other pre-established risk factors for CDAD.